Augmentin 457mg 100ml syrup

Description

Therapeutic action

Combination of two antibacterial. The addition of clavulanic acid to amoxicillin extends its spectrum of activity to cover beta-lactamase producing Gram-positive and Gram-negative organisms, including some Gram-negative anaerobes.

Indications

– Animal bites, if antibiotic therapy or antibiotic prophylaxis is clearly indicated

– Second line treatment of acute otitis media and acute bacterial sinusitis, when amoxicillin alone given at

high dose failed

– Acute uncomplicated cystitis (no systemic signs) in girls > 2 years

– Postpartum upper genital tract infection

– Severe pneumonia: parenteral to oral switch therapy in patients treated with ceftriaxone + cloxacillin

Presentation

– The ratio of amoxicillin and clavulanic acid varies according to the manufacturer:

Also comes in formultions with a ratio amoxicillin/clavulanic acid of 16:1, 14:1, 6:1, 2:1.

Dosage

(expressed in amoxicillin)

Animal bites; second line treatment of acute otitis media and acute sinusitis

• Child < 40 kg: 45 to 50 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1) or in 3 divided doses (if

using ratio 4:1)

Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day.

• Child ≥ 40 kg and adult: 1500 to 2000 mg/day depending on the formulation available:

Ratio 8:1: 2000 mg/day = 2 tablets of 500/62.5 mg 2 times per day

Ratio 7:1: 1750 mg/day = 1 tablet of 875/125 mg 2 times per day

Ratio 4:1: 1500 mg/day = 1 tablet of 500/125 mg 3 t

Duration

–Animal bites: 5 to 7 days;

-otitis media: 5 days; sinusitis: 7 to 10 days; cystitis: 3 days;

–upper genital tract infection: 7 days;

–parenteral to oral switch therapy in severe pneunonia: to complete a total of 10 to14 days of treatment.

Contra-indications, adverse effects, precautions

– Do not administer to penicillin-allergic patients and patients with history of hepatic disorders during a previous treatment with co-amoxiclav.

– Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).

– Administer with caution to patients with hepatic impairment; reduce dosage and give every 12 to

24 hours in patients with severe renal impairment.

– May cause: gastrointestinal disturbances (mainly diarrhoea); allergic reactions sometimes severe (stop

treatment immediately); jaundice and cholestatic hepatitis in the event of prolonged treatment (> 10 to

15 days).

Pregnancy: no contra-indication

Breast-feeding : no contra-indication

Remarks

– High doses of co-amoxiclav (80-100 mg/kg/day or 2.5-3 g/day) cannot be administered when using

formulations of amoxicillin/clavulanic acid in a ratio of 4:1 (the content in clavulanic acid is too high). The

maximum dose (expressed in amoxicillin) that can be given with these formulations is 50 mg/kg/day,

– Take with meals.

without exceeding 1500 mg/day.

Storage: below 25°C – –

Powder for oral suspension: between 15°C and 25°C

Once reconstituted, the oral suspension must be kept refrigerated (between 2°C and 8°C) and may be

used for up to 7 days.