Tinidazole 2g (4x500mg)

Description

Therapeutic action

– Antiprotozoal, antibacterial (group of nitroimidazoles)

Indications

– Amoebiasis, giardiasis, trichomoniasis

– Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp)

Presentation

– 500 mg tablet

Dosage and duration

– Amoebiasis

Child: 50 mg/kg once daily, without exceeding 2 g/day

Adult: 2 g once daily

The treatment lasts 3 days in intestinal amoebiasis; 5 days in hepatic amoebiasis.

–Giardiasis, trichomoniasis and bacterial vaginitis

Child: 50 mg/kg as a single dose, without exceeding 2 g

Adult: 2 g as a single dose

In the event of trichomoniasis, also treat sexual partner.

–Infections due to anaerobic bacteria

Child over 12 years and adult: initially 2 g then 1 g once daily or in 2 divided doses

According to indication, tinidazole may be used in combination with other antibacterials; treatment

duration depends on indication.

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to tinidazole or another nitroimidazole (metronidazole,

secnidazole, etc.).

– May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness.

Risk of antabuse reaction when combined with alcohol.

– Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin

(increased plasma concentrations of these drugs).

–Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.

–Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants);