Description
Therapeutic action
– Opioid antidiarrhoeal
Indications
– Symptomatic treatment of persistent diarrhoea in HIV patients, in combination with rehydration
Presentation
– 2 mg capsule or tablet
Also comes in 1 mg/5 ml oral solution.
Dosage
– Child from 2 to 5 years: 3 mg/day in 3 divided doses
– Child from 6 to 8 years: 4 mg/day in 2 divided doses
– Child over 8 years: 6 mg/day in 3 divided doses
– Adult: 4 mg (2 capsules), then 2 mg (1 capsule) after each loose stool, without exceeding 16 mg/day
(8 capsules/day)
Duration
– According to clinical response
Contra-indications, adverse effects, precautions
– Do not exceed indicated doses.
– Do not administer to children under 2 years.
– Do not administer to patients with bloody diarrhoea, acute inflammatory bowel disease, diarrhoea due
to antibiotics.
– May cause: constipation, allergic skin reactions, drowsiness, dizziness.
– In the event of overdosage, treat with naloxone.
–Pregnancy: no contra-indication
–Breast-feeding: no contra-indication
Remarks
– Rehydration is essential and must be adapted to the severity of diarrhoea.
– Loperamide is not included in the WHO list of essential medicine
Reviews
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