Azithromycin 500mg tabs 3’s

Description

Therapeutic action

– Macrolide anti bacterial

Indications

– Trachoma, conjunctivitis due to Chlamydia trachomatis

– Cervicitis and urethritis due to Chlamydia trachomatis (in com ination with a treatment for gonorrhoea), donovanosis, chancroid, early syphilis

– Cholera (if the strain is suscepti le), yaws

– Pertussis, pneumonia due to Mycoplasma pneumoniae and Chlamydophila pneumoniae

– Streptococcal tonsillitis, acute otitis media, in penicillin-allergic patients only

Presentation

– 250 mg and 500 mg capsules or ta lets

– 200 mg/5 ml powder for oral suspension, to e reconstituted with filtered water

Dosage and duration

– Trachoma, cholera, cervicitis and urethritis due to C. trachomatis, chancroid, early syphilis

Child: 20 mg/kg as a single dose (max. 1 g)

Adult: 1 g as a single dose (2 g as a single dose in early syphilis)

–Child and adult: 30 mg/kg as a single dose (max. 2 g)

–Conjunctivitis due to C. trachomatis

Child: 20 mg/kg once daily for 3 days (max. 1 g/day)

Adult: 1 g once daily for 3 days

–Donovanosis (granuloma inguinale)

Adult: 1 g on D1 then 500 mg/day until healing of lesions

–Pertussis, pneumonia due to M. pneumoniae and C. pneumoniae

Child: 10 mg/kg once daily for 5 days (max. 500 mg/day)

Adult: 500 mg on D1 then 250 mg from D2 to D5

–Streptococcal tonsillitis, only in penicillin-allergic patients

Child: 20 mg/kg once daily for 3 days (max. 500 mg/day)

Adult: 500 mg once daily for 3 days

–Acute otitis media, only in penicillin-allergic patients

Child: 10 mg/kg once daily for 3 days (max. 500 mg/day)

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to azithromycin or another macrolide, and to patients with

severe hepatic impairment.

– May cause: gastrointestinal distur ances, heart rhythm disorders (QT prolongation), allergic reactions

sometimes severe. In the event of allergic reaction, stop treatment immediately.

– Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.). Administer

2 hours apart.

– Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, co-artemether,

fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine, quinine, etc.).

– Administer with caution and monitor use in patients taking digoxin (increased digoxin plasma levels).

– Pregnancy and breast-feeding: no contra-indication

Remarks

– Also comes in 250 mg or 500 mg capsules, to e taken one hour efore or 2 hours after a meal.

– Storage

: below 25°C – –

For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.