Description
THERAPEUTIC ACTION
– Penicillin antibacterial
INDICATION
– Acute otitis media, streptococcal tonsillitis, sinusitis, bronchitis, pneumonia – Infection due to Helicobacter pylori (in combination with omeprazole and metronidazole or tinidazole), leptospirosis, no severe cutaneous anthrax – Typhoid fever (if ciprofloxacin is contra-indicated and if the strain is susceptible) – Completion treatment following parenteral therapy with penicillins or cephalosporins
PRESENTATION
– 250 mg and 500 mg tablets or capsules – 250 mg dispersible scored tablet, for paediatric use – 125 mg/5 ml powder for oral suspension, to be reconstituted with filtered water
DOSAGE
– Usual dosage (e.g. leptospirosis, tonsillitis, infection due to H. pylori) Child: 50 mg/kg/day in 2 divided doses Adult: 2 g/day in 2 divided doses – Severe infections (e.g. typhoid) or suspicion of resistant pneumococci (e.g. pneumonia, otitis) Child: 80 to 100 mg/kg/day in 3 divided doses (max. 3 g) Adult: 3 g/day in 3 divided doses
DURATION
– Otitis media: 5 days; tonsillitis : 6 days; leptospirosis: 7 days; pneumonia, sinusitis, cutaneous anthrax: 7 to 10 days; H. pylori infection : 10 to 14 days; typhoid fever: 14 days
PRECAUTION
– Do not administer to penicillin-allergic patients or patients with mononucleosis. – Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur). – May cause: gastrointestinal disturbances, allergic reactions, sometimes severe. In the event of allergic reaction, stop treatment immediately. – Reduce dosage in patients with severe renal impairment. – Do not combine with methotrexate. – Pregnancy and breast-feeding: no contra-indication
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